Pluronic® P123-coated liposomal codelivery of paclitaxel and lapatinib enhances therapeutic potential via tumor cell targeting and overcoming multidrug resistance in triple-negative breast cancer cells
نویسندگان
چکیده
Formulation and evaluation of Paclitaxel loaded PSA-PEG nanoparticlesRajat Sharma, Mohd Yasir, Sanjay Bhaskar, Asif
منابع مشابه
Therapeutic potential of ERK5 targeting in triple negative breast cancer
Triple negative breast cancers (TNBCs) account for 15% of all breast cancers, and represent one of the most aggressive forms of the disease, exhibiting short relapse-free survival. In contrast to other breast cancer subtypes, the absence of knowledge about the etiopathogenic alterations that cause TNBCs force the use of chemotherapeutics to treat these tumors. Because of this, efforts have been...
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Multidrug resistance (MDR) is a significant challenge to effective cancer chemotherapy treatment. However, the development of a drug delivery system that allows for the sustained release of combined drugs with improved vesicle stability could overcome MDR in cancer cells. To achieve this, we have demonstrated codelivery of doxorubicin (Dox) and paclitaxel (PTX) via a crosslinked multilamellar v...
متن کامل[Triple-negative breast cancer: molecular characteristics and potential therapeutic approaches].
The term triple-negative breast cancer (TNBC) defines breast tumors that do not express estrogen receptors, progesterone receptor or epidermal growth factor receptor HER2 on immunohistochemical analysis. TNBC accounts for 12-17% of all types of breast cancer. Molecular profiling indicated that triple-negative breast cancer represents a heterogeneous subgroup of breast cancer. Triple-negative br...
متن کاملTargeting triple-negative breast cancer: optimising therapeutic outcomes.
BACKGROUND Triple-negative breast cancer (TNBC) is a distinct subset of breast cancer (BC) defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2. It is highly heterogeneous and displays overlapping characteristics with both basal-like and BC susceptibility gene 1 and 2 mutant BCs. This review evaluates the a...
متن کاملOvercoming Multidrug Resistance in Cancer Stem Cells
The principle mechanism of protection of stem cells is through the expression of ATP-binding cassette (ABC) transporters. These transporters serve as the guardians of the stem cell population in the body. Unfortunately these very same ABC efflux pumps afford protection to cancer stem cells in tumors, shielding them from the adverse effects of chemotherapy. A number of strategies to circumvent t...
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ژورنال
عنوان ژورنال: journal of applied pharmaceutical science
سال: 2023
ISSN: ['2231-3354']
DOI: https://doi.org/10.7324/japs.2023.132946